Comparison of 2 Animation Packages

Toon Boom Studio

Pros:

The aspect of Toon Boom following a Traditional approach to animation.
Ability to work from an exposure sheet style, each scene step by step.
Onion Skin Tool which gives you the ability to view several previous and later drawings.
Lip Sync Tool allows you the option to preview how specific words should be synced to the mouth.
Pegs available allow motion to be delivered with the use of the camera; also, attaching your character to a peg using Toon Boom where the work will be done for you in giving the impression the character is moving closer or further from the camera (Toon Boom automatically adjusts the character proportions to how it would appear realistically).
Basic layout and drawing tools.

Cons:

Unable to provide a Motion Tween Tool like Flash.
More effort required for animation produces.

Flash Macromedia

Pros:

Motion Tween tool that flash provides allows the user to provide start and end keyframes and the package will complete the inbetweens.
Smoother animation.

Cons:

More of a technical approach, a tad confusing for animators starting out.